• The multiple regression analysis showed that testing during

  2022-06-10

  

  The multiple regression analysis showed that testing during summer and autumn was associated with higher histamine reactivity, which could be associated with the presence of pollen in the air. Gamboa et al. reported that more histamine was released during spring and autumn than during the other two

• Thus while there is ample

  2022-06-10

  

  Thus, while there is ample evidence to rule out a generalized blockade of TGF-ß signaling by Hippo pathway activation upon establishment of cell–cell contacts, more recent studies have established that, in specific contexts, Hippo and TGF-ß signaling may either interfere or cooperate with each other

• In our previous study we designed and synthesized

  2022-06-10

  

  In our previous study, we designed and synthesized compounds of A series from the starting material 4-hydroxy-3-methoxycinnamic 87 8 (ferulic acid). These compounds with R group being amino acid residues, fatty acyl group and sulfuryl group showed moderate HDAC inhibition and in vitro antitumor pot

• clofibrate br cAMP cGMP effector systems in human platelets

  2022-06-10

  

  cAMP/cGMP effector systems in human platelets (PKA, PKG, PDEs) In eukaryotic cells, the effects of intracellular cAMP are mediated by two types of cAMP-dependent protein kinases (PKA type I and II) and cAMP-regulated guanine nucleotide exchange factors (EPAC/cAMP-GEF) which activate the RAS GTPas

• FOLE was recently approved for use in PN dependent patients

  2022-06-09

  

  FOLE was recently approved for use in PN-dependent patients in the United States. However, potential adverse effects of FOLE, including bleeding risk, and effects on the immune system [8], [39], render its use in certain patient populations controversial. Identification of key downstream modulators

• Based on the role of NMDA receptors in initiation

  2022-06-09

  

  Based on the role of NMDA receptors in initiation and propagation of epileptic seizures and on potentiation of NMDA function by glycine, it has been hypothesized that glycine will have proconvulsant activity (Foster and Kemp, 1989). Indeed, there is some evidence that human epileptogenic foci, remov

• IBs had a clear vesicular ultrastructure

  2022-06-09

  

  IBs had a clear vesicular ultrastructure, suggesting that a large part of the iron-containing mitochondrial remnants might be cleared via normal autophagy processes during final reticulocyte maturation [21]. IB formation was followed by characteristic changes in RBC morphology, with irregularly shap

• br Recent insights into EAAT structure function aspects The

  2022-06-09

  

  Recent insights into EAAT structure/function aspects The EAATs are secondary-active transporters coupling the movement of one Glu with the symport of three Na+ and one proton and the counter-transport of one K+ [3, 4]. The transporters are trimeric assemblies of protomers that function independen

• Although EAAT may not be involved in

  2022-06-09

  

  Although EAAT3 may not be involved in the induction of morphine-induced CPP, our results suggest that other EAATs may play a role in the behavior because riluzole, an EAAT activator (Frizzo et al., 2004, Fumagalli et al., 2008), abolished morphine-induced CPP. Consistent with this suggestion, a few

• br Regulation of Glu transporters The pivotal role of

  2022-06-09

  

  Regulation of Glu transporters The pivotal role of Glu transporters in the fine tuning and turnover of this excitatory amino (3S,5S)-Atorvastatin sodium salt calls for a detailed characterization of its regulation. Several general mechanisms that modify Glu uptake activity have been described. T

• In order to elucidate the reasons of high efficacy

  2022-06-09

  

  In order to elucidate the reasons of high efficacy of , we evaluated the BOC group itself and the linkage between the BOC group and the benzene ring of A-part. Urea moiety (), the replacement of an oxygen nuclear receptor of the BOC group to a nitrogen atom, decreased the activity (EC = 0.12 μM), wh

• Multiple mechanisms have been suggested by

  2022-06-09

  

  Multiple mechanisms have been suggested by which glucagon can increase energy expenditure although none have been conclusively proven to be responsible. Both enhanced gluconeogenesis and enhanced protein turnover secondary to hyperglucagonaemia have been suggested as the reason for the increased met

• hoechst stain synthesis The regulation of gap junction conne

  2022-06-09

  

  The regulation of gap junction-connexin-mediated activities may be achieved through action on the channel gating properties (membrane voltage, pH, interaction with junctional and cytoskeletal proteins, Ca2+ and K+ concentrations, etc) or on the trafficking, turnover and localization of connexins. Sh

• The chemical structure of BAs consists of

  2022-06-09

  

  The chemical structure of BAs consists of a steroid nucleus with an acidic side chain. They are amphipatic molecules characterized by a hydrophilic α-face and a hydrophobic β-face. The hydrophobic pocket of the FXR LBD interacts with BAs largely through the β-face. The α-face contains several hydrox

• br Conclusions Osteoclcastogenesis is regulated

  2022-06-09

  

  Conclusions Osteoclcastogenesis is regulated by multiple signal transduction pathways. To maintain bone homeostasis, osteoclast cells must achieve a balance regulation of formation, function, and trafficking of its precursors. Here, we proposed a model in which crosstalk between Fas and S1P/S1P1

14436 records 353/963 page Previous Next First page 上5页 351352353354355 下5页 Last page