• Verapamil HCl: Beyond Calcium Blockade—Emerging Roles in ...

  2025-09-23

  Verapamil HCl, a phenylalkylamine L-type calcium channel blocker, is gaining attention for its multifaceted roles in research, including apoptosis induction in myeloma cells and inflammation attenuation in arthritis models. This article explores novel molecular insights and translational applications, positioning Verapamil HCl at the interface of calcium signaling, apoptosis, and bone biology.

• Pioglitazone as a PPARγ Agonist: Novel Mechanistic Insigh...

  2025-09-22

  Explore the multifaceted utility of pioglitazone, a potent PPARγ agonist, in dissecting insulin resistance mechanisms and inflammator

• WY-14643 (Pirinixic Acid): Advancing Metabolic Disorder R...

  2025-09-19

  Explore the multifaceted applications of WY-14643 (Pirinixic Acid), a selective PPARα agonist, in metabolic disorder research and tumor microenvironment studies. This article examines mechanistic insights, recent findings, and practical considerations for using WY-14643 in scientific investigations.

• VX-765: Advancing Caspase-1 Inhibition in Inflammation an...

  2025-09-18

  Explore the scientific advances enabled by VX-765, a selective oral caspase-1 inhibitor, in dissecting inflammatory signaling and pyroptosis. This article details VX-765's utility in modulating IL-1β and IL-18 release, its applications in disease models, and its role in mechanistic cell death studies.

• Last decade has provided a number

  2025-03-03

  

  Last decade has provided a number of studies indicating that AhR signaling could play a role both in the development and in progression of multiple cancer types, with potential implications for cancer therapy (for review see (Kolluri et al., 2017; Murray et al., 2014)). Activation of AhR is consider

• Adiponectin also suppresses inflammatory stimuli induced NF

  2025-03-03

  

  Adiponectin also suppresses inflammatory stimuli-induced NF-kappaB activation, which may significantly contribute to the anti-diabetic and anti-atherogenic effects of adiponectin (Ouchi et al., 2000). The downstream mediators of AdipoR1 and AdipoR2, RPPAR and AMPK increase inflammatory responses by

• Role of APPL in endosomal signaling

  2025-03-03

  

  Role of APPL in endosomal signaling pathways Endosomes consist of distinct membrane subdomains within individual organelles and assist in the translation of extracellular stimuli via cytoplasmic transduction cascades to the nucleus [3], [74]. Endosomal abnormalities are associated with the pathogen

• The second evidence comes from

  2025-03-03

  

  The second evidence comes from the results obtained by patch-clamp recordings carried out at the endplate region of isolated mouse FDB fibers, where adenosine and the P1R agonist NECA significantly affected the NPo, the open frequency and the time constant τ of the adult nAChR channels. It is genera

• Since the cloning of ARs in the beginning of the

  2025-03-03

  

  Since the cloning of ARs in the beginning of the 1990s, the efforts to characterize them have led to the accumulation of a substantial amount of experimental data. Decades of site-directed mutagenesis (SDM; Box 1) studies, in combination with pharmacological data and computational modeling, have pav

• The physiological effect of adenosine is now considered

  2025-03-03

  

  The physiological effect of adenosine is now considered a new direction in halting the progression of organ damage in cardiovascular disease [24], [25], [26]. Adenosine has diverse functions, depending on its interaction with different receptor subtypes: A1, A2A, A2B, and A3[24], [25], [26]. Stimula

• In vitro studies with soman inhibited

  2025-03-03

  

  In vitro studies with soman-inhibited, non-aged AChE revealed a species dependent reactivating potency of HI-6 and MMB-4. With guinea pig AChE second order reactivation rate constants of 0.051 and 0.038mM−1min−1 were determined for HI-6 and MMB-4, respectively (Luo et al., 2007). Corresponding value

• Although we have achieved a great deal of success

  2025-03-03

  

  Although we have achieved a great deal of success in the development of tools to understand autophagy in health and disease, highly specific reagents for autophagy manipulation and deep knowledge of autophagy is required to advance the research in therapeutic treatment. Better disease (ischemia) ani

• lactic acid br Conclusion In summary screening a

  2025-03-03

  

  Conclusion In summary, screening a small compound library based on the 3-aminopyridin-2-one motif in a target-blind manner against a 26-kinase panel, representative of the kinome, identified hits that possess good activity and excellent ligand efficiency against MPS1, Aurora A and Aurora B. The b

• Mitochondrial dysfunction resulting from mtDNA abnormalities

  2025-03-01

  

  Mitochondrial dysfunction resulting from mtDNA abnormalities may trigger retrograde signaling pathways from the mitochondrion to the nucleus, which regulate the expression of genes involved in diverse cellular processes, including metabolism, stress responses, tumor progression, nutrient sensing, li

• Antagonist G MiR has already been implicated in the protecti

  2025-03-01

  

  MiR-21 has already been implicated in the protective effects of Res on lung fibrosis, but the molecular mechanisms are underexplored. Our results showed a clear increase of activation protein 1 (AP-1) activity after TGF-β treatment, which was suppressed by Res in a dose-dependent manner, suggesting

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