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In agreement with the evidence on the
2020-06-08
In agreement with the evidence on the Plg-binding function of tapeworm enolases, eukaryotic enolases have been shown to be multifunctional proteins, with other activities besides their role as glycolytic enzymes (Pancholi, 2001). In this respect, several flatworms have been proved to express enolase
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In this study we investigated whether
2020-06-08
In this study, we investigated whether the Ednra signaling is involved in Hoxa9/Meis1-mediated leukemogenesis. We found an upregulation of Ednra in leukemic murine bone marrow (BM) duvelisib australia overexpressing Hoxa9 and Meis1 compared to cells overexpressing Hoxa9 alone. We showed that overex
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A comparative analysis of the cleavage activity
2020-06-08
A comparative analysis of the cleavage activity of different forms of the BoNT/A endopeptidase in reduced conditions with SNAPtide and full-length SNAP-25 substrate is summarized in Fig. 5, Fig. 6. The BoNT/A LC was found to be the most active against SNAPtide, a small peptide segment of the SNAP-2
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In our opinion the precise function
2020-06-08
In our opinion, the precise function of AE of S. mansoni (Sm32) remains unclear, and accurate knowledge of the three dimensional structure of this enzyme would be valuable for a better understanding the molecular basis of many of its properties, including its role in the host-parasite interaction, a
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br EBV Infection Epstein Barr virus
2020-06-08
EBV Infection Epstein–Barr virus (EBV, human herpesvirus 4) was discovered 50 years ago, when Epstein, Achong, and Barr used electron microscopy to identify viral particles in Burkitt\'s lymphoma cells. It belongs to the lymphocryptovirus (LCV) genus of the gammaherpesvirus subfamily (Fig. 1A). T
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PPM-18 br Author contribution br Acknowledgements We want
2020-06-08
Author contribution Acknowledgements We want to thank Dr. Manuel Rodriguez, Dr. Ch. Blattner, Dr. Jorge Moscat, Dr. Erwin Knecht and Dr. Peter Tontonoz for materials. This work has been supported by grants from the Spanish Ministry of Education and ScienceSAF2011-27442 and a grant from General
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Then what is the solution to
2020-06-08
Then what is the solution to tackle DNA damage-induced metabolic decline? The culprit here may be not DNA damage signaling per se, but rather the persistent activation of the DNA damage signaling pathways due to age-related accumulation of DNA damage. DNA repair, including repair by NHEJ, is an esse
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Introduction Rotavirus RV a member of Reoviridae family is
2020-06-08
Introduction Rotavirus (RV), a member of Reoviridae family, is a non-enveloped virus which has a double-stranded RNA genome of 11 segments surrounded by three concentric protein layers. It has been reported to cause estimated 25% of moderate-to-severe illnesses (Kotloff et al., 2013) and 30% of tot
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Introduction The term myeloproliferative disorders was first
2020-06-08
Introduction The term “myeloproliferative disorders” was first proposed by William Dameshek in 1951. With the discovery of the Philadelphia chromosome, myeloproliferative disorders were classified into two groups: BCR-ABL positive chronic myeloid leukemia (CML) and BCR-ABL negative chronic myelopro
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AMD is equally active against a broad range of HIV
2020-06-08
AMD3100 is equally active against a broad range of HIV-1 and HIV-2 strains, but not against simian immunodeficiency virus (SIV) strains in human PBMC (De Clercq et al., 1994). At this moment it is not clear what coreceptor SIV is using in human PBMC, but it does not seem to be CXCR-4 (Feng et al., 1
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ICV injection of UCN or
2020-06-08
ICV injection of UCN2 or UCN 3 performed in the morning of the 8th day (12h after the last IP administration) seems to increase further the time spent in the open arms of mice exposed to saline or nicotine treatment. Interestingly, in mice exposed to saline treatment ICV injection of UCN 2 or UCN 3
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Higher versus lower order skills can also
2020-06-05
Higher versus lower order skills can also be understood in the context of the CPA exam. The CPA exam tests four broad topics (FAR, AUD, BEC, REG) using three different testing modes: multiple-choice, task-based simulations and written communications. Combined, the three testing modes place more emph
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Udenafil also has shown the
2020-06-05
Udenafil also has shown the ability to significantly inhibit the decrease of vascular endothelial cell function and inhibit the decrease in endothelial cell and smooth muscle contents, thus preventing their fibrosis within the penile corpus cavernosum in diabetic or hyperlipidemic animal models when
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SJB3-019A br Materials and methods br Results
2020-06-05
Materials and methods Results Discussion We have evaluated the breast cancer prevention potential of PR blockade under conditions that included exposure to progestogens that are relevant to women (progesterone and MPA) and are known to differ in their receptor-binding and down-stream effect
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br Results br Discussion Many studies have
2020-06-05
Results Discussion Many studies have shown that intrinsic properties of the E2 enzyme govern the nature of the Ub modification, including both the multiplicity of the Ub modification and the specific WAY-600 type in the case of polyubiquitin chains [3], [4], [9], [14]. Whereas previous studie
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