• During the course of our optimization of

  2021-11-11

  

  During the course of our optimization of the diarylsulfonamide chemotype as FFA4 agonists, we identified xanthene as a potent and selective antagonist of FFA4 (). Xanthene was able to block the agonist induced intracellular Ca response elicited by both linoleic GDC0068 and compound in competitio

• Although angiogenesis is crucial for cerebral ischemic

  2021-11-11

  

  Although angiogenesis is crucial for cerebral ischemic rehabilitation, the mechanism underlying NGF promotion of angiogenesis is not clear. Previous studies showed that angiogenesis can be promoted by FAK, in a breast cancer model [19]. Recent studies showed that FAK phosphorylation participated in

• PKC does not however directly stimulate secretion

  2021-11-11

  

  PKC does not, however, directly stimulate secretion by initiating calcium influx into the cell [51]. Work from multiple groups measuring calcium currents has shown that PMA alone or coupled with glucose does not modulate intracellular calcium influx [34], [51], [52], [53]. Instead of contributing to

• Thus both in Drosophila and mammals

  2021-11-11

  

  Thus, both in Drosophila and mammals, the Hippo pathway responds to cell–cell junctions via an apical NF2/Mer-containing complex. Indeed, Hippo signalling and NF2 are required for contact inhibition of growth in cell culture, which is thought to reflect an in vivo function as a sensor of tissue crow

• Acknowledgments The authors thank Partners Healthcare for fi

  2021-11-10

  

  Acknowledgments The authors thank Partners Healthcare for financial support. This work was also supported in part by NIH Grant R01CA122608 to J.M.G.H. Introduction The phosphorylation of histone H3 is recognized as a hallmark of mitosis. Histone H3 phosphorylation at Thr3 (H3T3ph) acts as a mit

• The observed glucose intolerance and elevated fasting blood

  2021-11-10

  

  The observed glucose intolerance and elevated fasting blood glucose in this study is in consonance with earlier study (Ferris and Kahn, 2012). These have been the common features of GC exposure and are not unexpected. Previous researches that reported IR during GC exposure have shown controversy con

• To date glycine receptors have been found in

  2021-11-10

  

  To date, glycine receptors have been found in five distinct transmembrane protein subunits (one β subunit and four α subunit (α1–α4)), combining to form two different types of functional receptors [4], [14], either α homomeric, the immature extrasynaptic glycine receptor subtype, or αβ heteromeric,

• Although we showed that RBL H Sc cells took up

  2021-11-10

  

  Although we showed that RBL-2H3 Sc98 pathways cu took up histamine from the microenvironment, it was unclear which transporter mediated its passage across the plasma membrane. Other biogenic amines have selective transporters that belong to the neurotransmitter sodium symporter family, including SE

• aa utp To maintain low Glu concentrations in the synaptic cl

  2021-11-10

  

  To maintain low Glu concentrations in the synaptic cleft below the affinity of its receptors, this amino aa utp is rapidly removed from the extracellular space by a family of sodium-dependent high-affinity transport systems located mainly in the plasma membrane of perisynaptic astrocytes, and in to

• Excessive extracellular glutamate may induce excitotoxic neu

  2021-11-10

  

  Excessive extracellular glutamate may induce excitotoxic neuronal damage in disorders of the CNS (Schwartz et al., 2003). EAATs are considered to contribute to prevention of excitotoxicity by glutamate uptake. Our data revealed that expression levels of membrane EAAT proteins in astrocytes are much

• Ca independent release of L C glutamate

  2021-11-10

  

  Ca2+-independent release of L-[14C]glutamate and [3Н]GABA that occurs via transporters working in the reverse mode also insignificantly increased in vitamin D3 deficiency despite decreased GAT-3 and EAAC-1 Cy3-dUTP and neurotransmitter uptake efficacy Fig. 3, Fig. 6 A). However, the upward tendency

• br Materials and methods br Results br Discussion Employment

  2021-11-10

  

  Materials and methods Results Discussion Employment of GIPR signaling, specifically the direction of this manipulation, as a strategy to improve body weight remains a contentious subject of intense scientific investigation [22], [32], [33]. Despite the physiological benefits of GIP on enzas

• bgj398 br Materials and methods br Results br Discussion G

  2021-11-10

  

  Materials and methods Results Discussion G-quadruplex structures are extensively studied for its role in central dogma of molecular biology viz. replication problems leading to chromosomal translocations [20], [21], transcriptional inhibition [32] and alternative splicing and translational

• To investigate the potential molecular mechanism of FXR

  2021-11-10

  

  To investigate the potential molecular mechanism of FXR-mediated regulation of liver cancer cell proliferation, gene expression profiles were determined using Agilent arrays in SK-Hep-1-FXR and NC after treatment with the FXR agonist GW4064. The results indicate that mTOR and S6k are involved in div

• br Introduction Farnesoid X receptor FXR is

  2021-11-10

  

  Introduction Farnesoid X receptor (FXR) is a bile benfotiamine receptor regulated nuclear receptor highly expressed in the liver, intestine, kidney and adrenal glands in rodents.1, 2, 3, 4 FXR regulates transport proteins, the bile salt export pump (BSEP) and the organic solute transporter α (OS

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