• Recently a lot of synthetic

  2022-01-18

  

  Recently, a lot of synthetic FFA1 agonists containing acidic moieties have been reported (Fig. 1) [13], [14], [15], [16], [17], [18], [19], [20], [21]. Notably, most of FFA1 agonists usually have the common biphenyl scaffold, which resulted in a relative deprivation in structure types of agonists [2

• All of the abovementioned effects of

  2022-01-18

  

  All of the abovementioned effects of PUFAs signal their involvement in a cellular phenotype switching phenomenon, which is increasingly recognized as a potential target for future pharmacotherapies of atherosclerosis, especially for individuals who do not respond to the classical lipid-lowering stra

• Macroautophagy hereafter referred to as autophagy

  2022-01-18

  

  Macroautophagy (hereafter referred to as autophagy) depends on an intracellular lysosome-dependent degradation system that maintains cellular metabolism and homeostasis [11]. Genes involved in these processes are termed autophagy-related genes (ATGs), which regulate autophagosome formation and compl

• br Acknowledgements This work was in part supported

  2022-01-18

  

  Acknowledgements This work was in part supported by the FöFoLe program by Ludwig-Maximilians-Universität München (to T.S.), the Deutsche Forschungsgemeinschaft (DFG) CO 291/5-2, the Human Frontier Science Program (HFSP) RGP0013, the Helmholtz Validation Funds (Helmholtz Association of German Rese

• Interestingly the subcellular localization of FBPase in

  2022-01-18

  

  Interestingly, the subcellular localization of FBPase in hepatocytes and proximal tubule Disuflo Cy3 azide reveals that FBPase is also able to translocate to the nucleus in these cell types. The nuclear localization of muscle-FBPase was recently reported [35]. This data corroborate our results on th

• Following the discovery of diketo compounds S and L

  2022-01-17

  

  Following the discovery of β-diketo compounds S-1360 [31] and L-731988 [32] as anti-HIV integrase inhibitors, a group of researchers discovered a potent Nitrendipine synthesis based derivative (1) as the inhibitor of HIV integrase functioning at the 3′-processing and strand transfer steps of HIV in

• A revolution in cancer immunotherapy has recently

  2022-01-17

  

  A revolution in cancer immunotherapy has recently emerged with the development of novel immunomodulatory antibodies, classified as immunostimulatory agonist monoclonal closantel (mAbs) or checkpoint blocking mAbs. CD40/CD40L, as an important costimulatory pathway, mediates a broad spectrum of system

• br Conclusion Whilst acknowledging that

  2022-01-17

  

  Conclusion Whilst acknowledging that forensic science critically needs strategic investment across every domain [27], forensic science needs to bring both ‘hedgehog’ and ‘fox’ approaches together to address the roots of the major challenges the discipline faces. Addressing these challenges in a w

• PLP has been found to be effective inhibitor of many

  2022-01-17

  

  PLP has been found to be effective inhibitor of many enzymes that have Nogo-66 (1-40) for phosphate-containing substrates or effectors, including RNA polymerase [14], [15], reverse transcriptase [16], and DNA polymerase [17], [18]. Oka et al. [19], [20] reported that vitamin B6 deficiency generally

• The biological function of NPRA is demonstrated primarily th

  2022-01-17

  

  The biological function of NPRA is demonstrated primarily through the ANP/BNP-dependent GC catalytic activity of the receptor and the production of cGMP, which is regulated by several factors, including hormones, growth factors, physiological milieu, and the ligand itself [26,34,[36], [37], [38], [3

• Pharmacologic approaches of inhibiting GSNOR activity

  2022-01-17

  

  Pharmacologic approaches of inhibiting GSNOR activity have reached the point of clinical development with the recent announcement of the first cystic fibrosis patients treated with the first-in-class GSNOR inhibitor, N6022 (N30 Pharmaceuticals). Clinical development is ongoing for other indications

• Recent work by Que et al with mouse models implicates

  2022-01-17

  

  Recent work by Que et al with mouse models implicates GSNOR in the cause of asthma. GSNOR is expressed in multiple cell types in the lung, including airway epithelial cells and infiltrating leukocytes. After exposure to ovalbumin, GSNOR activity increased in airway lining fluid, perhaps reflecting i

• 7-Nitroindazole Migratory properties of Treg are extremely i

  2022-01-17

  

  Migratory properties of Treg are extremely important for the potential in vivo application. Therefore, the observed expression of CXCR3 on almost all obtained insulin-specific Treg is crucial for directing 7-Nitroindazole into the inflamed tissue (in this case pancreatic islets). CXCR3 responds to C

• br Vesicular glutamate transporters VGLUTs br Conclusions Du

  2022-01-17

  

  Vesicular glutamate transporters (VGLUTs) Conclusions Due to the molecular cloning of EAAT and VGLUT subtypes, a better understanding of the functional properties of these carriers has been elucidated over the last few years. In the case of the EAATs, specific blockers, such as trans-2,4-PDC,

• br Introduction Ghrelin is a amino acid

  2022-01-17

  

  Introduction Ghrelin is a 28-amino 94 8 peptide mainly produced in the stomach and small intestines with the kidneys, placenta, and pancreas contributing to miniscule amounts of circuiting ghrelin [1]. Ghrelin exists in circulation in two major forms: acyl ghrelin (AG) and desacyl ghrelin (DAG).

15138 records 481/1010 page Previous Next First page 上5页 481482483484485 下5页 Last page