Archives
- 2018-07
- 2019-04
- 2019-05
- 2019-06
- 2019-07
- 2019-08
- 2019-09
- 2019-10
- 2019-11
- 2019-12
- 2020-01
- 2020-02
- 2020-03
- 2020-04
- 2020-05
- 2020-06
- 2020-07
- 2020-08
- 2020-09
- 2020-10
- 2020-11
- 2020-12
- 2021-01
- 2021-02
- 2021-03
- 2021-04
- 2021-05
- 2021-06
- 2021-07
- 2021-08
- 2021-09
- 2021-10
- 2021-11
- 2021-12
- 2022-01
- 2022-02
- 2022-03
- 2022-04
- 2022-05
- 2022-06
- 2022-07
- 2022-08
- 2022-09
- 2022-10
- 2022-11
- 2022-12
- 2023-01
- 2023-02
- 2023-03
- 2023-04
- 2023-05
- 2023-06
- 2023-08
- 2023-09
- 2023-10
- 2023-11
- 2023-12
- 2024-01
- 2024-02
- 2024-03
- 2024-04
- 2024-05
- 2024-06
- 2024-07
- 2024-08
- 2024-09
- 2024-10
- 2024-11
- 2024-12
- 2025-01
- 2025-02
- 2025-03
-
br NLS and NES Mapping br Sequence Comparison of
2022-03-08
NLS and NES Mapping Sequence Comparison of Gli NLSs—NLSs in ZF Domains Alignment of the Gli NLSs of representative metazoan animals suggests that the amino Cy5 amine (non-sulfonated) residues in the ZF domains are strongly conserved (Figure 4.2, Figure 4.3B). However, the length of the interve
-
Conclusions br Author information The obtained
2022-03-07
Conclusions Author information The obtained models of complexes of FPR2 with most of the described compounds are freely available at the author’s web site: http://www.biomodellab.eu/models/. Acknowledgements This work was partly done at the Interdisciplinary Centre for Mathematical and Compu
-
Recently we indicated that cell motility was
2022-03-07
Recently, we indicated that cell motility was regulated by the different induction of GPR120 and GPR40 in liver epithelial WB-F344 BDS I treated with chemical agents. The cell motility of WB-F344 cells was stimulated by phorbol ester 12-O-tetradecanoylphorbol-13-acetate (TPA) which is a potent tum
-
Histone demethylases are involved in the transcriptional
2022-03-07
Histone demethylases are involved in the transcriptional output of the AR and hypoxia signaling pathways, and thus contribute to prostate cancer development [12]. For example, the histone demethylase KDM3A serves as a transcriptional coactivator of HIF1α and AR in regulation of their target genes [1
-
To identify structurally novel autophagy inhibitors a medium
2022-03-07
To identify structurally novel autophagy inhibitors, a medium throughput screen of our in-house library of approximately 160,000 compounds was performed. In the screening assay, MCF7 egfr pathway stably transfected with eGFP-tagged light chain 3 (LC3), were employed, which can be detected by automa
-
The observed glucose intolerance and elevated fasting blood
2022-03-07
The observed glucose intolerance and elevated fasting blood glucose in this study is in consonance with earlier study (Ferris and Kahn, 2012). These have been the common features of GC exposure and are not unexpected. Previous researches that reported IR during GC exposure have shown controversy con
-
br Introduction Initial studies of cancer metabolism in the
2022-03-07
Introduction Initial studies of cancer metabolism in the early 1920s showed that the cancer phenotype for glucose metabolism is unique, with increased abilities to take up glucose and produce lactate, even under aerobic conditions [1]. This pathway, called aerobic glycolysis or the Warburg effect
-
NHS Biotin br Materials and methods br Results br Discussion
2022-03-07
Materials and methods Results Discussion Although there is general agreement that GPR109A has anti-lipolytic activity and that the NEFA reduction in response to nicotinic NHS Biotin is mediated by GPR109A, whether GPR109A activation has any impact on plasma TG levels is unclear. Since the p
-
br Materials and methods br Results br Discussion Until very
2022-03-07
Materials and methods Results Discussion Until very recently, the anti-atherogenic activity of niacin was attributed almost exclusively to its impact on HDL and other plasma lipids, perhaps mediated via its action on GPR109A expressed in adipose or other tissues. However, recent clinical st
-
In the present study we aimed
2022-03-07
In the present study, we aimed to investigate the effect of a common dairy and beef genetic background on the mRNA Helioxanthin derivative 5-4-2 of the AdipoQ system and GPR109A in different adipose depots and liver. Materials and Methods Results Comparing fat masses between families (fat-ty
-
The importance of FXR FGF signaling in BA
2022-03-07
The importance of FXR-FGF15/19 signaling in BA homeostasis is illustrated by various BA malabsorption syndromes. Clinically, BA malabsorption causes diarrhea due to high BA concentrations in the colon that lead to secretion of water and electrolytes and stimulation of propulsive contractions [36]. P
-
Purmorphamine Thermal analysis of the NQ peptide was
2022-03-07
Thermal analysis of the NQ21 peptide was performed with the Solar CM2203 spectrofluorometer. We prepared three 1 μg/mL peptide solutions with different Purmorphamine levels (5.0, 7.4, 8.5) in 0.01 M phosphate buffers. Each solution was slowly heated up from 28 °C to 54 °C with a step of 1 °C. Spect
-
br Presenilins in protein trafficking proteolysis
2022-03-04
Presenilins in protein trafficking, proteolysis and degradation An obvious explanation for the role of presenilins and γ-secretase in protein trafficking and degradation is that many reported γ-secretase substrates are functionally involved in protein transport. For example, members of the mammal
-
br Introduction Conversion of visual input into electrical i
2022-03-04
Introduction Conversion of visual input into electrical information and routing this information to the brain is the main function of the eye (Levin et al., 2011). These processes require a microenvironment that offers adequate supply with oxygen and nutrients and also removal of all unwanted and
-
Liver is the house for a variety of xenobiotic
2022-03-04
Liver is the house for a variety of xenobiotic-metabolizing NB-598 that produce reactive oxygen species as well as reactive metabolites (Johansson et al., 2009; Noh et al., 2017; Puntarulo and Cederbaum, 1998). When the enzymes act upon pre- or pro-haptens, the chemicals would be activated to react
15088 records 451/1006 page Previous Next First page 上5页 451452453454455 下5页 Last page