• In this study there is a limitation in

  2022-06-07

  

  In this study, there is a limitation in the study of sex differences. Only female rats were used in our study. This is because the rats cannot urinate autonomously after SCI. Manual Ketanserin emptying was needed until reflex bladder emptying was established (Lu et al., 2008, Ma et al., 2015). Becau

• Introduction Cancer has been a significant public health pro

  2022-06-07

  

  Introduction Cancer has been a significant public health problem in the world with more patients being diagnosed every year. However, chemotherapy from non-specific cytotoxic agents that as an effective means of cancer treatment is limited by severe side effects and poor selectivity. Thus, the deve

• Estrus expression after removal of

  2022-06-07

  

  Estrus CA-074 Me after removal of P4 insert and before TAI is a clear predictor of greater P/AI in protocols that use GnRH [6,8], EB, or ECP [10,18] as ovulation inducers. Therefore, our third hypothesis was that heifers showing estrus behavior would have greater P/AI, which was supported in both tr

• TXA has been shown to be a competitive antagonist

  2022-06-06

  

  TXA has been shown to be a competitive antagonist on the GABAA receptor and potentially also the glycine [7], [12], [15] receptor. Furtmuller et al. showed that TXA right-shifted the GABA CRC by one order of magnitude [7], while in our study TXA similarly right-shifted the GABA EC50 value from 0.33 

• br Declaration of interest br

  2022-06-06

  

  Declaration of interest Acknowledgments This work was supported by grants from the Polish National Science Centre (PRELUDIUM grant no. 2013/11/N/NZ5/00270) and the European Commission FP7 Project Beta-JUDO (grant number 279 153), European Union EIT Health project DeTecT2D, Swedish Diabetes A

• Aspartame Historically a role for the prefrontal cortex in s

  2022-06-06

  

  Historically, a role for the prefrontal cortex in spatial working memory has been repeatedly claimed (for review, see Kolb, 1984). Older studies using traditional, non-fibre-sparing lesions (e.g. aspiration lesions) often resulted in spatial alternation deficits. In contrast, more recent studies emp

• The orientation of the immobilized enzyme may affect its act

  2022-06-06

  

  The orientation of the immobilized enzyme may affect its activity and stability and therefore the final biocatalyst performance. Since proteins present areas more prone to unfolding in their surface or near to it [36], the immobilization through these areas may improve the final biocatalyst stabilit

• All of the abovementioned effects of PUFAs signal

  2022-06-06

  

  All of the abovementioned effects of PUFAs signal their involvement in a cellular phenotype switching phenomenon, which is increasingly recognized as a potential target for future pharmacotherapies of atherosclerosis, especially for individuals who do not respond to the classical lipid-lowering stra

• br Introduction A great many

  2022-06-06

  

  Introduction A great many isoprenoids with varieties of structural diversity, such as steroids, carotenoids, prenyl quinones, and natural rubber, occur in nature. All of these biosynthetic precursors are constructed by the action of prenyl chain elongating enzymes [1], [2], [3], [4]. These enzyme

• Over the last decade intense efforts have been devoted

  2022-06-06

  

  Over the last decade, intense efforts have been devoted toward identifying IN inhibitors as potential drugs against HIV. Raltegravir and elvitegravir are integrase strand transfer inhibitors (INSTIs) that have been approved for therapy and dolutegravir is another INSTI that is currently in advanced

• H R antagonism can prevent seizure development and improve w

  2022-06-06

  

  H3R antagonism can prevent seizure development and improve working memory through the activation of histaminergic neurons (Huang et al., 2004, Zhang et al., 2003). In addition, we have recently found that H3R antagonism protects against ischemia-reperfusion injury via histamine-independent mechanism

• br Materials and methods br Results br

  2022-06-06

  

  Materials and methods Results Discussion The major findings of the present study are that: 1) the response to inverse agonists may be crossregulated by the activation of either LY2940680 H1 or H2 receptors, 2) histamine H1 and H2 receptor inverse agonists crossdesensitize the receptor´s re

• br STAR Methods br Acknowledgments We thank the TCGA PanCanA

  2022-06-06

  

  STAR★Methods Acknowledgments We thank the TCGA PanCanAtlas Analysis Working Group. This study was supported in part by grants from the NIH (CA175486 and CA209851 to H.L., CA217842 to G.B.M., and CCSG grant CA016672); a grant from the Cancer Prevention and Research Institute of Texas (RP140462

• Recently CFS has been included in

  2022-06-05

  

  Recently, CFS has been included in the group “low cystine and glutamine syndromes,” which are characterized by a combination of abnormally low plasma levels of these two aminoacids, as well as reduced natural killer cell activity, and increased rates of urea production [13]. Some studies indicated

• Alzheimer s disease AD is

  2022-06-05

  

  Alzheimer's disease (AD) is a neurodegenerative disorder and characterized by the presence of abnormal filamentous protein inclusions in nerve cells of the brain [2]. The neuropathological hallmarks of AD were first reported by Alois Alzheimer and date back to 1907 [3], [4]. These inclusions are for

15136 records 402/1010 page Previous Next First page 上5页 401402403404405 下5页 Last page