Archives

  • 2018-07
  • 2019-04
  • 2019-05
  • 2019-06
  • 2019-07
  • 2019-08
  • 2019-09
  • 2019-10
  • 2019-11
  • 2019-12
  • 2020-01
  • 2020-02
  • 2020-03
  • 2020-04
  • 2020-05
  • 2020-06
  • 2020-07
  • 2020-08
  • 2020-09
  • 2020-10
  • 2020-11
  • 2020-12
  • 2021-01
  • 2021-02
  • 2021-03
  • 2021-04
  • 2021-05
  • 2021-06
  • 2021-07
  • 2021-08
  • 2021-09
  • 2021-10
  • 2021-11
  • 2021-12
  • 2022-01
  • 2022-02
  • 2022-03
  • 2022-04
  • 2022-05
  • 2022-06
  • 2022-07
  • 2022-08
  • 2022-09
  • 2022-10
  • 2022-11
  • 2022-12
  • 2023-01
  • 2023-02
  • 2023-03
  • 2023-04
  • 2023-05
  • 2023-06
  • 2023-08
  • 2023-09
  • 2023-10
  • 2023-11
  • 2023-12
  • 2024-01
  • 2024-02
  • 2024-03
  • The studies from several laboratories suggest that miR famil

    2019-04-30

    The studies from several laboratories suggest that miR-34 family members are the direct targets of TP53, and their upregulation can induce cancer cell apoptosis and cell-cycle arrest. It has been found that miR-34 is associated with prognosis, carcinogenesis, and survival of various cancers, including ovarian cancer, gastric cancer, and many other cancers. Only three studies reported a potential association between miR-34b/c rs4938723 and HCC risk. However, all these studies were conducted in Asian populations. A common primary transcript (pri-miR-34b/c), which was induced by p53 in response to genotoxic stress, was shared by mMiR-34b and miR-34c; miR-34b/c is considered to be a tumor-suppressor miRNA. In another meta-analysis, the authors revealed that there is no association between miR-34b/c rs4938723 polymorphism, and colorectal cancer and breast cancer. In our meta-analysis, none of the genetic models produced a significant association between miR-34b/c rs4938723 polymorphism and HCC susceptibility.
    Introduction Since 2010, China has become the world’s second largest economy. The middle-class population has been increasing dramatically in China’s big cities, whereas the majority of rural residents remain financially impoverished. The average income of Chinese farmers is one-fourth of that made by urban residents; this wide gap between the average incomes of urban and rural residents led to the 5-Azacytidine of a large number of rural laborers into the city. According to the Chinese National Bureau of Statistics, although the average income (2609 yuan per month) of these migrant laborers in Chinese cities is considerably higher than the income earned by rural farmers, it remains relatively low compared to that of urban residents. However, such migrant employment provided extra jobs to increase the household income, which prompted these people to become migrant laborers (or nong-min-gong in Mandarin). China ranks among the countries with the largest migrant laborer populations in the world. The majority of the Chinese workforce consists of rural migrants, who are those special groups doing physical work under the household registration system. An earlier survey of Chinese migrant population provides the definition of the migrant laborers: those who have been absent from rural locations for more than 6 months, although their registered permanent residence remains in rural areas. A unique institution was established in 1958, which effectively constrained citizens of specific areas in China through residency permits. Since China thereafter implemented reform policy and “opened up” to the world in 1978, the volume of international migration and internal migration has been rising steeply. In this study, we primarily focus on internal migration within China. Migration has become one of the most significant phenomena over the past few decades. A survey of China’s National Health and Family Planning Commission shows that the country is experiencing the most massive population movement in history, from 6 million in the 1980s to 245 million in 2013. This has been accompanied by a period of rapid development of urbanization, which results in a sustained growth of the migrant laborer population in subsequent years. Overall, this information suggests that there is one migrant worker for every six people in China. The large-scale migrant populations and their associated issues attract great interest from the social sciences community. Among several studies, some contrasted the differences between migrants and nonmigrants in certain areas, whereas others examined the variation of factors across groups of migrants. These investigations included studies focusing on the informal urbanization process that occurs in mass migrants, the social status among migrants in urban areas, migrant living conditions, and possible solutions. Health condition is a key determinant that includes ample relevant factors among migrant laborers due to societal and economic development in China. Exploring the health status of migrants is important to promote disease prevention, health promotion programs, and the delivery of appropriate health and social services to the migratory population. Health status has an influence on the incomes of migrant laborers because migrants have to reduce their working days or even forego working when health problems arise.